Retatrutide is a multi-agonist peptide that activates GLP-1, GIP, and glucagon receptors, studied for its broad influence on metabolism, weight regulation, and energy expenditure. By combining these signaling pathways, it is used in research to evaluate synergistic effects on glucose homeostasis, lipid metabolism, and thermogenesis. Studies investigate how this triple-agonist approach compares with single- or dual-receptor agents in modulating appetite and promoting metabolic flexibility. Researchers also examine its effects on liver fat, insulin dynamics, and long-term energy balance in experimental models. For research use only. Not approved for human consumption.